Recent News About
Frederic Bantignies
Visiting Fulbright Scholar

Frederic Bantignies is a CNRS Research Associate of the « Institut de Génétique Humaine » in Montpellier, France. Using Drosophila as a model organism, his research focuses on nuclear organization and gene regulation by Polycomb-group and trithorax-group proteins, which are chromatin factors involved in many cellular processes and cancers. Recently, many higher order structures along the chromatin fiber have been identified, partitioning the genomes into well-demarcated physical domains, also called “Topologically associating domains” (TADs). Specific connections among these TADs, including Polycomb domains, may participate in the functional folding of genomes into the nucleus. Since September 2012, granted by the CNRS and The Fulbright Association, he joined the lab of Ting Wu for a sabbatical year, with the aim of using the Oligopaint technology and high-throughput FISH analysis to identify the molecular networks that lay behind this specific chromosome organization.


Three-dimensional folding and functional organization principles of the Drosophila genome.
Sexton T., E. Yaffe, E. Kenigsberg, F. Bantignies, B. Leblanc, M. Hoichman, H. Parrinello, A. Tanay and G. Cavalli. Cell. 2012 Feb 3;148(3):458-72.

Polycomb group proteins: repression in 3D.
Bantignies F. and G. Cavalli.
Trends Genet. 2011 Nov;27(11):454-64.

Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila.
Bantignies F., V. Roure, I. Comet, B. Leblanc, B. Schuettengruber, J. Bonnet, V. Tixier, A. Mas and G. Cavalli.
Cell. 2011 Jan 21;144(2):214-26.

Chromatin folding: from linear chromosomes to the 4D nucleus.
Cheutin T., F. Bantignies, B. Leblanc and G. Cavalli.
Cold Spring Harb Symp Quant Biol. 2010;75:461-73.

Polycomb group-mediated gene silencing mechanisms: stability versus flexibility.
Roure V. and F. Bantignies.
Epigenomics. 2009 Dec;1(2):301-18.

Genomic interactions: chromatin loops and gene meeting points in transcriptional regulation.
Sexton T., F. Bantignies and G. Cavalli.
Semin Cell Dev Biol. 2009 Sep;20(7):849-55.

Polycomb response elements mediate the formation of chromosome higher−order structures in the bithorax complex.
Lanzuolo C., V. Roure, J. Dekker, F. Bantignies and V. Orlando.
Nat Cell Biol. 2007 Oct;9(10):1167-74. Epub 2007 Sep 9.

Cellular memory and dynamic regulation of polycomb group proteins.
Bantignies F. and G. Cavalli.
Nat Cell Biol. 2007 Oct;9(10):1167-74. Epub 2007 Sep 9.

RNAi components are required for nuclear clustering of Polycomb group response elements.
Grimaud C., F. Bantignies, M. Pal-Bhadra, P. Ghana, U. Bhadra and G. Cavalli.
Cell. 2006 Mar 10;124(5):957-71.

Polycomb group-dependent Cyclin A repression in Drosophila.
Martinez A.M., S. Colomb, J. Déjardin, F. Bantignies and G. Cavalli.
Genes Dev. 2006 Feb 15;20(4):501-13.

Inheritance of Polycomb-dependent chromosomal interactions in Drosophila.
Bantignies F., C. Grimaud, S. Lavrov, M. Gabut and G. Cavalli.
Genes Dev. 2003 Oct 1;17(19):2406-20.