Recent News about Eric
Eric Joyce
Postdoctoral Fellow
Ph. D. in Genetics and Microbiology, Rutgers University
RESEARCH

My primary goal is to identify the factors required for somatic homolog pairing. I am using FISH to conduct genome-wide RNAi-driven screens for mutants that alter the fidelity of homolog pairing in Drosophila and then will characterize the genetic pathways that are identified. To address cancer directly, I am also working with Brian Beliveau to generate low-cost high-resolution chromosome paints that will permit analyses of human tumor types and cell lines as well as a screen of the human genome for pairing factors.

PUBLICATIONS

Germline Progenitors Escape the Widespread Phenomenon of Homolog Pairing during Drosophila Development.
Joyce EF, Apostolopoulos N, Beliveau BJ, Wu CT.
PLoS Genet. 2013 Dec;9(12):e1004013. doi: 10.1371/journal.pgen.1004013. Epub 2013 Dec 19.PMID: 24385920

Versatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes
Beliveau BJ, Joyce EF, Apostolopoulos N, Yilmaz F, Fonseka CY, McCole RB, Li JB, Senaratne TN, Williams BR, Rouillard JM, Wu CT.
Proc Natl Acad Sci USA. 2012. 109(52):21301-6

Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen.
Joyce E.F., Williams B.R., Xie T., Wu C.-t..
PLoS Genet 2012. 8(5) : e1002667. doi:10.1371/journal.pgen.1002667.

Multiple Barriers to Non-homologous DNA End Joining During Meiosis in Drosophila.
Joyce E.F., Paul A., Chen K.E., Tanneti N.S., McKim K.S.
Genetics. 2012 Apr 27.

A Pathway for Synapsis Initiation during Zygotene in Drosophila Oocytes.
Tanneti N.S., Landy K., Joyce E.F., McKim K.S.
Curr Biol. 2011 Oct 25. [Epub ahead of print]

Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair.
Joyce E.F., Pedersen M., Tiong S., White-Brown S.K., Paul A., Campbell S.D., McKim KS.
J Cell Biol. 2011 Oct 24.

Meiotic checkpoints and the interchromosomal effect on crossing over in Drosophila females.
Joyce E.F. & McKim, K.S.
Fly (Austin). 2011 Apr 1:5(2).

Drosophila I-R hybrid dysgenesis is associated with catastrophic meiosis and abnormal zygote formation.
Orsi, G.A., Joyce E.F., Couble, P., McKim, K.S. & Loppin, B.
Journal of Cell Science. 2010 Sep 14.

Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis.
Joyce E.F., & McKim, K.
PLoS Genetics 2010 Aug 12;6(8).

Cytological analysis of meiosis in fixed Drosophila ovaries.
McKim, K.S., Joyce E.F. & Jang, J.K.
Methods Mol. Biol. 2009; 558:197-216

Drosophila hold'em is required for a subset of meiotic crossovers and interacts with the dna repair endonuclease complex subunits MEI-9 and ERCC1.
Joyce E.F., Tanneti, N.S. & McKim, K.S.
Genetics 2009 Jan;181(1):335-40. Epub 2008 Oct 28.

Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formation.
Joyce E.F. & McKim, K.S.
Genetics 2009 Jan;181(1):39-51. Epub 2008 Oct 28.

When specialized sites are important for synapsis and the distribution of crossovers.
Joyce E.F. & McKim, K.S.
Bioessays 2007 Mar;29(3):217-26.