Recent News About
Guy Nir
postdoctoral fellow
Ph.D. in Biophysics, Bar Ilan University
Personal Website and Lab Notebook

The spatiotemporal organization of chromatin is considered to be a fundamental aspect of almost every cellular activity that requires DNA accessibility, including replication, gene expression, homolog pairing and segregation.  In particular, I am interested in visualizing genome organization at different scales using super-resolution microscopy. For example, at, small genomic scales, I will be asking how local sub-chromosomal repositioning can alter genomic activity, such as gene co-regulation. At higher genomic scales, I will be exploring the structural progression of chromatin from its smallest units of function (as small as a single nucleotide, to genes, regulatory regions, and TADs) to the organization of an entire chromosome (telomere to telomere) and, ultimately, the genome.