Matt Jakubik
GRADUATE STUDENT

B.S. in Biochemistry, Muhlenberg College
B.S. in Russian Studies, Muhlenberg College

RESEARCH

The pairing of maternal and paternal homologous chromosomes is a process commonly associated with meiosis; however, it is becoming more apparent that homolog pairing and other interchromosomal interactions are a common occurrence in somatic cells and may play an important role in the regulation of genes and chromatin structure. My research will investigate if homolog pairing alters chromatin structure using chromatin mapping and footprinting techniques. Additionally, previous work has shown that homolog pairing is essential for certain trans regulatory interactions in D. melanogaster, namely transvection via enhancer action in trans and transvection via insulator bypass. Current models posit that homolog pairing-mediated changes to gene topology are responsible for insulator bypass. I will investigate if such topological constraints are responsible for this interaction.