Recent News about Niroshi
Niroshi Senaratne
Graduate Student
A.B. in Biology (2009), Harvard College
 
 
RESEARCH

Diploid organisms possess two copies of each chromosome, one homolog that is inherited maternally and one homolog that is inherited paternally. Additionally, following DNA replication, each chromosome will possess an identical sister chromatid, giving rise to four chromosomes that share homology in a G2 nucleus. I am interested in how these chromosomes relate to one another, both in terms of the mechanisms involved and their functional implications. Sister chromatids are held together by the cohesin protein complex, which keeps them connected until their separation in mitosis. In Drosophila and other dipteran insects, maternal and paternal homologs are closely associated as a result of somatic pairing in virtually all cell types throughout development. My project focuses on the relationship between sister chromatid cohesion and somatic homolog pairing, which has implications for the nature of the pairing mechanism, the processes of homolog recognition, and the connection between pairing and the cell cycle.

PUBLICATIONS

Distribution Pattern of Plasmodium falciparum Chloroquine Transporter (pfcrt) Gene Haplotypes in Sri Lanka 1996-2006.
Zhang JJ, Senaratne TN, Daniels R, Valim C, Alifrangis M, Amerasinghe P, Konradsen F, Rajakaruna R, Wirth DF, Karunaweera ND.
Am J Trop Med Hyg. 2011. 85(5): 811-814.

Uterine leiomyomas exhibit fewer stem/progenitor cell characteristics when compared with corresponding normal myometrium.
Chang HL, Senaratne TN, Zhang L, Szotek PP, Dombkowski D, Preffer F, Donahoe PK, Teixeira J.
Reprod Sci. 2010. 17(2): 158-167