sneha_profile
Sneha Grandhi
Postdoctoral Fellow

PhD Genetics and Genome Sciences, Case Western Reserve University, USA, (2018).

BSc Genomics and Molecular Genetics, Michigan State University, USA (2012).

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Summary

I am a highly enthusiastic and creative scientist investigating selective pressures placed on the human genome. I’ve garnered significant skills in bioinformatics, computational genomics, data mining, next generation sequencing, cell culture, grant writing, and public speaking.


Background

I received my bachelor’s degree in Genomics and Molecular Genetics with a minor in Mathematics from Michigan State University in 2012. With an interest in computational genomics, I joined Dr. Thomas LaFramboise’s lab at Case Western Reserve University where I went on to earn my doctoral degree in Genetics and Genome Sciences in 2018.


During my graduate career, I acquired a strong skillset in big data analysis and biostatistics, which was funded by two graduate research fellowships from NIH (NCI F31 NRSA and NIGMS CMBTP) and resulted in six peer-reviewed scientific publications, two freeware software packages, two productive collaborations, and several awards (see below).


Research

I joined the Wu lab in July 2018 to understand selective pressures on highly conserved DNA sequences in the contexts of health and disease. Broadly, my project focuses on understanding the function and mechanism of ultra-conserved DNA elements (UCEs), with a specific interest in their role in fertility and fetal viability in humans.


My publications

Mitochondrial genomics in the cancer cell line encyclopedia and a scoring method to effectively pair cell lines for cytoplasmic hybridization.
Grandhi, S., L., Wang, J., Grandhi, A., & LaFramboise, T. (2018).
Mitochondrion.

Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection.
Grandhi, S.,Bosworth, C., Maddox, W., Sensiba, C., Akhavanfard, S., Ni, Y., & LaFramboise, T. (2017).
Human Molecular Genetics, ddx172.

Detection and quantification of mitochondrial DNA deletions from next-generation sequence data.
Bosworth, C. M., Grandhi, S., Gould, M. P., & LaFramboise, T. (2017).
BMC bioinformatics, 18(12), 407.

Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonu`cleotide reductase.
Knappenberger, A. J., Grandhi, S., Sheth, R., Ahmad, M. F., Viswanathan, R., & Harris, M. E. (2017).
Journal of Biological Chemistry, 292(40), 16463-16476.

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR mt to promote metastasis.
Kenny, T. C., Hart, P., Ragazzi, M., Sersinghe, M., Chipuk, J., Sagar, M. A., Eliceiri, K.W., LaFramboise, T., Grandhi, S., Santos, J., & Riar, A. K. (2017).
Oncogene, 36(31), 4393.

PCR-Free Enrichment of Mitochondrial DNA from Human Blood and Cell Lines for High Quality Next-Generation DNA Sequencing.
• Gould, M. P., Bosworth, C. M., McMahon, S., Grandhi, S., Grimberg, B. T., & LaFramboise, T. (2016).
PloS one, 11(5), e0156884.ome.

Selected Awards

o 2018 Doctoral Excellence Award (Genetics) April 2018 – Issued by CWRU School of Medicine Graduate Program Directors

o NIH NCI F31 Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship (May 2016 – June 2018) Funded by the National Cancer Institute, received this award for the duration of three years, rescinded the last year upon graduation.


o NIH NIGMS Cell and Molecular Biology Training Grant (July 2015 – June 2016) Funded by the National Institute for General Medical Sciences, this inter-departmental award supports eight pre-doctoral students per year within CWRU’s School of Medicine who display exceptional academic and research potential.


o Charles J. Epstein Trainee Award for Excellence in Human Genetics Research (ASHG Semifinalist) (Oct 2016) Merit-based award issued by the American Society of Human Genetics Program Committee to top-scoring and highly competitive abstracts.


Hobbies

In my free time, I enjoy singing and playing bass guitar, traveling, and petting cats.