Son C. Nguyen
Graduate Student
B.A. in Genetics, Rutgers University
 
 
RESEARCH

Interest in Suppressor 2 of zeste (Su(z)2) stems from its homology to Posterior sex combs (Psc), an important chromatin regulator in Drosophila. Psc is a core protein of the Polycomb Repressive Complex 1 (PRC1) and is involved in gene regulation primarily through the maintenance of gene silencing. While both Psc and Su(z)2 are essential for viability, much remains to be learned about the functions of Su(z)2 in development. Therefore, a comprehensive strategy involving both genetics and biochemistry will be used to elucidate these functions. First, I will conduct mutagenesis screens to identify key residues of Su(z)2. Second, I will carry out genetic studies to clarify the functional importance of these residues in vivo. Third, I will apply the information obtained from my genetic studies to a biochemical analysis of Su(z)2 function. The combination of both genetic and biochemical analyses will paint a picture of Su(z)2 that should be more accurate than obtained from either of the approaches alone.

PUBLICATIONS

Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells.
Serrano L, Liang L, Chang Y, Deng L, Maulion C, Nguyen S, Tischfield JA.
Stem Cells Dev. 2011 Feb;20(2):363-74.

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks.
Liang L, Deng L, Nguyen SC, Zhao X, Maulion CD, Shao C, Tischfield JA.
Nucleic Acids Res. 2008 Jun;36(10):3297-310.

Reduced apoptosis and increased deletion mutations at Aprt locus in vivo in mice exposed to repeated ionizing radiation.
Liang L, Mendonca MS, Deng L, Nguyen SC, Shao C, Tischfield JA.
Cancer Res. 2007 Mar 1;67(5):1910-7.